New study links severe sleep apnea to higher blood glucose levels in African Americans

Suggests that targeting sleep may help prevent diabetes and improve treatment.

Tuesday, April 28, 2020

African Americans with severe sleep apnea and other adverse sleep patterns are much more likely to have high blood glucose levels — a risk factor for diabetes — than those without these patterns, according to a new study funded in part by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health.

The findings suggest that better sleep habits may lead to better blood glucose control and prove beneficial for type 2 diabetes prevention and diabetes management in African Americans, who are at higher risk for type 2 diabetes than other groups. They also point to the importance of screening for sleep apnea to help fight the potential for uncontrolled blood sugar in this high-risk group, the researchers said.

Previous studies have linked disturbed sleep patterns, including sleep apnea, to increased blood glucose levels in white and Asian populations. But this new study is one of the few to use objective measurements to link these disturbed sleep patterns to increased blood glucose levels in black men and women, the researchers said. Their findings appear online on April 28 in the Journal of the American Heart Association.

“The study underscores the importance of developing interventions to promote regular sleep schedules, particularly in those with diabetes,” said Yuichiro Yano, M.D., Ph.D., the lead study author and a researcher in the Department of Family Medicine and Community Health at Duke University. “It also reaffirms the need to improve the screening and diagnosis of sleep apnea, both in African Americans and other groups.”

Michael Twery, Ph.D., director of the NHLBI’s National Center on Sleep Disorders Research, added that the study highlights important associations between untreated sleep apnea and poorly-regulated blood sugar. “It also adds to growing evidence that protecting our sleep, like diet and exercise, may help reduce the risk of diabetes and the related risk of cardiovascular disease.”

For the study, the researchers evaluated sleep patterns while concurrently measuring blood glucose markers among 789 black men and women who were enrolled in the Jackson Heart Study, the largest study of cardiovascular disease in African-Americans. Most of the participants—74%—were women, 25% had type 2 diabetes, 20% were taking diabetes medication, and about 57% had a diagnosis of obstructive sleep apnea but were not receiving treatment for their condition, Yano said. Their mean age was 63 years.

Participants completed at-home sleep apnea tests, and each used a wrist actigraph watch, a tool that measures wakefulness and sleep, for seven days. The test calculated sleep duration (short vs long), sleep efficiency, night-to-night variability in sleep duration, and sleep fragmentation (multiple disruptions during sleep). The researchers obtained several measures of glucose metabolism, including fasting blood glucose concentration, HbA1c levels, and insulin resistance.

The researchers focused on four main groups: regular sleepers (no sleep apnea), those with mild sleep apnea, moderate sleep apnea, and severe sleep apnea. During the course of the study, they found that those with the severe sleep apnea had 14% higher fasting blood glucose levels compared to those without sleep apnea. Severe sleep apnea was also associated with higher HbA1c levels, Yano said.

In addition to studying sleep apnea, the researchers found that participants who experienced other types of disturbed sleep—including sleep fragmentation and sleep duration variability—were also more likely to have increased measures of blood glucose. The associations between disturbed sleep and high blood glucose levels were stronger in participants with diabetes compared to those without diabetes, the researchers said. In those without diabetes, disturbed sleep was also associated with increased insulin resistance.

Yano and his team also found that associations of sleep apnea and high blood glucose levels were stronger among black men than black women. Black men with severe sleep apnea had 10% higher fasting blood glucose levels than black women with severe sleep apnea in the study.

The researchers noted interventions that treat sleep apnea might help improve blood glucose management, including the use of continuous positive air pressure (CPAP) machines — devices that deliver air through a mask to keep the airway open when worn during sleep — and the encouragement of better sleep patterns in blacks, particularly in those with diabetes. But further studies will be needed to determine if such interventions will be effective, Yano said.

Research reported in this study was supported NHLBI through R01HL110068. Additionally, co-author Susan Redline, M.D., MPH, was supported in part by 5R35HL135818, and co-author Dayna Johnson, Ph.D., MPH, was supported in part by K01HL138211. The Jackson Heart Study is supported and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), the Mississippi State Department of Health (HHSN268201800015I/HHSN26800001) and the University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I, and HHSN268201800012I) contracts from the NHLBI and the National Institute on Minority Health and Health Disparities.

About the National Heart, Lung, and Blood Institute (NHLBI): NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. For more information, visit www.nhlbi.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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Study

Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study DOI: 10.1161/JAHA.119.013209

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